One way to hold this word: a line that used to run between you and someone, and is now dead. The people have not disappeared. The is still your , the number is still in your phone — nobody calls. What makes estranged heavy is exactly that the closeness is still on record while the contact has stopped, so a familiar person has turned into a stranger. English then runs the same dead line between a person and a thing: a hometown, a company, a team you gave your childhood to.
From the word’s history
The source describes this word as meaning 'having become a stranger, of one who formerly was close', and lists it as the past participle of the verb estrange. So the stranger inside the word is not decoration: the form says someone was made strange.
資料裡把這個字解釋為「本來親近的人,變成了陌生人」,並且標明它是動詞 estrange 的過去分詞。所以字裡的 strange(陌生)不是巧合:這個形態說的就是「被變成了陌生人」。
Packet evidence: Wiktionary entry 'estranged' — adj gloss 'Having become a stranger, of one who formerly was close…' (wikt:estranged:adj:0) and verb gloss 'simple past and past participle of estrange' (wikt:estranged:verb:0).
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